These proteins use the type V secretion system toĮxport bacterial components from cytosol to the extracellular milieu ( Henderson, Navarro-Garcia, Desvaux, Fernandez &Īla'Aldeen, 2004). Reported mainly in Gram-negative bacteria ( Alamuri In the last two decades, new virulence proteins known as autotransporters have been
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Promote bladder and kidney colonization during infection ( Coker, Poore, Li & Mobley, 2000 Armbruster & Mobley, 2012). mirabilis involves the expression of virulenceįactors, as adherence, motility and evasion of the host immune response, which Periurethral abscesses, bacteremia, urolithiasis and prostatitis ( Allison, Coleman, Jones & Hughes, 1992). mirabilis are: acute pyelonephritis, chronic inflammation, Some of the most frequent urinary pathologies caused by mirabilis causesĬomplicated urinary tract infections (UTI), mainly in patients having urinaryĬatheters for prolonged periods or in those with structural or functionalĪbnormalities of the urinary tract ( Mobley &īelas, 1995).
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It is frequently isolatedįrom the gastrointestinal tracts of humans and animals ( Hoeninger, 1964). Lengthened cell with multiple flagella (swarmer cell) ( Coker, Poore, Li & Mobley, 2000 O'Hara, Branner & Miller, 2000). Varies from a simple vegetative bacillus with few flagella (swimmer cell) to a Member of the Enterobacteriaceae family ( Coker, Proteusmirabilis is a mobile dimorphic Gram-negative #1 bacterium Palabras clave: Pet (Plasmid-encoded toxin) Proteus mirabilis infección del tracto urinario citoesqueleto órganos urinarios mirabilis (Pet+)Ĭontribuye a la patogenicidad y afecta tejidos urinarios durante el curso de la Las alteracionesĭel citoesqueleto fueron observadas en los sitios donde se detectó Pet. Se confirmó la presencia de Pet en las célulasĮxfoliadas y en las del parénquima por microscopía confocal. Se observaron múltiples célulasĮxfoliadas del epitelio de transición de la vejiga, así como alteraciones Morfológicos fueron evidenciados por histología. Riñón desde el segundo hasta el día decimo de la infección. Mirabilis (Pet+) muestran una colonización bacteriana en vejiga y mirabilis (Pet+)įue inducida en ratones hembras BALB/c. (ITU) en pacientes que usan catéteres o que presentan anomalías estructurales oįuncionales. mirabilis causa infección en el tracto urinario Recientemente, Pet fue encontrada en el genoma de una cepa de La toxina Pet (plasmid-encoded toxin) producida por EscherichiaĬoli (EAEC) es uno de los autotransportadores más estudiados en laĮs responsable de cambios morfológicos en enterocitos durante la infección porĮAEC. Key words: Pet (Plasmid-encoded toxin) Proteus mirabilis urinary tract infection cytoskeleton urinary organs
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Pathogenicity, affecting urinary tissues during the course of the infection. mirabilis (Pet+) strain, contributes to its The presence of Pet intoĮxfoliated and parenchymal cells was confirmed by confocal microscopy.Ĭytoskeleton alterations were observed in those sites where Pet was detected. Structural cell alterations in the kidney cortex. Multiple exfoliated roundedĬells were observed in the bladder transitional epithelium, as well as, Morphological changes were evidenced by histology. In bladder and kidney, from the second up to the tenth day post-infection. mirabilis (Pet+) showed bacterial colonization In this study, an UTI was induced inīALB/c female mice with the P. Urinary tract infections (UTI) in patients having urinary catheters and Recently, Pet was found in the genome of the It is responsible of morphological changes inĮnterocytes during EAEC infection. The plasmid-encoded toxin (Pet) is one of the most studied EnterobacteriaceaeĪutotransporters produced by the enteroaggregative EscherichiaĬoli (EAEC).